Clinical diagnostic services
Cytochrome P450
Genetic Analysis
A tool for effective drug prescription
What is Cytochrome P450?
Cytochrome P450 represents a major set of drug-metabolising enzymes. Although there are many P450 genes, three (2C9, 2D6 and 2C19) are responsible for the metabolism of most commonly used drugs. They are highly polymorphic and vary between individuals. This leads to variability in response to drug therapy.
Why chose the Cytochrome P450 test?
Variability in drug response between individuals is a major problem leading to therapeutic failure or adverse effects in a significant number of patients. The Cytochrome P450 test will guide the clinician to:
- which medications will work most effectively and at what dosage
- which treatments might cause adverse reactions and/or react with other concurrent treatments
Who should be tested?
Recent annual statistics for the United Kingdom alone show that adverse or ineffective drug response accounts for an estimated 20,000 deaths and over half a billion pounds in healthcare costs. The following may benefit:
- Patients who have previously experienced adverse drug reactions
- Patients who show no improvement to existing drug therapy
- Patients receiving multiple medications
- Patients initiated on chronic therapies
- Cancer and psychiatric patients where ‘trial and error’ is high risk
Product
sheet
All Inclusive Module
Product
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Drug Gene Module
What is the test?
The genotyping of Cytochrome P450 is performed on a mucosal sample collected by a buccal swab. The results are evaluated against millions of clinical and genetic parameters by the Signature Genetics™ knowledge base to provide a personalised patient report.
From receipt of the patient samples at our testing laboratory, a report will be sent within 15
working days.
