Testing for Hereditary Breast & Ovarian Cancer (HBOC) Syndrome
Proactive cancer management through early risk identification
What is BRACAnalysis®?
The Myriad BRACAnalysis® test assesses a woman’s risk of developing breast or ovarian cancer based on detection of mutations in the BRCA1 and BRCA2 genes. Individuals with BRCA1 or BRCA2 mutations have a 50% (or 1 in 2) chance of passing that mutation on to each of their children.
Who should be tested?
Individuals with a personal and/or family history of any of the following may benefit from BRCA1 and/or BRCA2 mutation testing using BRACAnalysis®:
- Early onset of breast cancer prior to age 50
- Ovarian cancer at any age
- Multiple breast and/or ovarian cancer diagnoses in an individual or a family
- Women of Ashkenazi Jewish descent diagnosed with breast cancer prior to age 50, or ovarian cancer of any age, regardless of family history
- Male breast cancer
How can I order BRACAnalysis® from Lab21?
BRACAnalysis® testing requires a blood sample, and it can only be requested by a medical doctor. To request BRACAnalysis® BRCA testing service, simply contact Lab21 customer services by
Phone: +44 (0)1223 395 450
Email: info@lab21.com
The turnaround time is 21 working days from the receipt of the sample at Lab21. A rapid option with 12-day turnaround time is also available.
References
Beaudet AL, Tsui LC. A suggested nomenclature for designating mutations. Hum Mut 1993; 2:245-248.
Petrij-Bosch A et al. BRCA1 genomic deletions are major founder mutations in Dutch breast cancer patients. Nat Gen 1997; 17:341-345
The BRCA1 Exon 13 Duplication Screening Group. The Exon 13 duplication in the BRCA1 gene is a founder mutation present in geographically diverse population. Am J Hum Gen 2000; 67:207-212
Rohllfs EM et al. An Alu-mediated 7.1kb deletion og BRCA1 exons 8 and 9 in breast and ovarian cancer families that results in the splicing of exon 10. Genes Chr & Cancer 2000 ; 28 :300-307.
Armstrong K et al. Assessing risk of breast cancer. N Engl J Med. 2000; 342:564-71.
Myriad and BRACAnalysis are either trademarks or registered trademarks of Myriad Genetics, Inc in the United States and other jurisdictions.
BRACAnalysis® Service
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Lab21 Customer Services
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Email: info@lab21.com
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To request BRACAnalysis®, your first point of contact is the dedicated Lab21 Customer Services Team who handles:
- Test Requests and Customer Support
- Sample logistics from Customer to Lab21
- Forwarding of sample to Myriad Genetic Laboratories, US, for testing
- Reporting of the Results
The BRACAnalysis® options from Lab21 are:
- Comprehensive BRACAnalysis®: Comprehensive analysis of BRCA1 and 2 gene mutations
- BRACAnalysis®: BRCA1: Comprehensive BRCA1 gene mutation test
- BRACAnalysis®: BRCA2: Comprehensive BRCA2 gene mutation test
- Single Site BRACAnalysis®: Analysis of a Single Mutation in BRCA1 or BRCA2 gene
- Multisite 3 BRACAnalysis®: Analysis of founder mutations in BRCA 1 & 2 genes (Ashkenazi)
- Reflex BRACAnalysis®: Comprehensive BRAC gene mutation test following negative result from Multisite 3
- BART: BRACAnalysis® rearrangement test
Testing is performed at Myriad Genetic Laboratories, US, in a CAP and CLIA approved laboratory. All mutations and genetic variants are named according to the convention of Beaudet and Tsui1.
The turnaround time is 21 working days from receipt of sample at Lab21. A rapid option with 12-day turnaround time is also available for Comprehensive, Multisite 3 and BRACAnalysis®.
Myriad and BRACAnalysis are either trademarks or registered trademarks of Myriad Genetics, Inc in the United States and other jurisdictions.